反应详情

温度

65 °C

To a solution of propargyl bromide (80% solution in toluene, 500 δ 3.36 mmol) in acetone (15 ml) at 23° C. was added 2-phenyl phenol (316 mg, 1.86 mmol) and potassium carbonate (1.05 g, 7.61 mmol). After being stirred in a sealed reaction vial at 65° C. for 14 hours, the reaction was concentrated in vacuo, the residue purified by flash chromatography (ethyl acetate:hexane: 9:1) to afford compound 5 in 95% yield. 1H NMR(CDCl3) δ 2.45-2.55 (m, 1H), 4.60-4.70 (m, 2H), 6.99-7.43 (m, 9H).

1. concentrationthe reaction was concentrated in vacuo
2. customthe residue purified by flash chromatography (ethyl acetate:hexane: 9:1)