Triethylamine → HCID 21262483, compound

HRID 567673Notes

Reaction equation

HRID 567673 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(N(CC)CC)C.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](Cl)=O>C1(C)C=CC=CC=1>[CH3:11][C:8]1[CH:9]=[CH:10][C:2]2[N:1]=[C:24]([C:23]3[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=3[O:21][C:20]([F:19])([F:31])[F:32])[O:5][C:4](=[O:6])[C:3]=2[CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 762552-Amino-5-methylbenzoic acidHCID 27772412-(Trifluoromethoxy)benzoyl Chloride

Product 1

HCID 21262483HCID 21262483, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Amino-5-methylbenzoic acid (0.5 g) and triethyl amine (10 ml) were mixed in dry toluene (20 ml). 2-Trifluoromethoxybenzoyl chloride (1.64 g) was added dropwise under cooling and stirring. The mixture was subsequently heated to RT for 2 days.

Workup

  1. temperatureunder cooling

Sources & evidence

ORD record
ord-b163b98321a840e1b339261c0b468144
Source dataset
uspto-grants-2001_01
Patent number
US06180625B2

Reaction notes

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