Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitrogen → 2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | 2-Amino-5-nitrobenzoic acid | HCID 12032 | — |
| 반응물 | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| 용매 | Toluene triethylamine | HCID 22504574 | — |
| 생성물 | 2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one | HCID 21262464 | — |
반응 단계
5-Nitroanthranilic acid (0.6 g) was dissolved in triethyl amine/toluene (1/1) (18 mL) and stirred for 10 min. 2,6-Difluorobenzoylchloride (1.3 g) was slowly added under stirring which resulted in the formation of a precipitate. The reaction was performed in an N2-atmosphere. After stirring at RT for 24 h the mixture was extracted with sat.NaHCO3 and ethyl acetate (20 mL), the organic layer was separated and evaporated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06180625B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-799a40c324144e02bf5f287d1693f394 |
| 출처 메모 | uspto-grants-2001_01 |