2-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one → 7-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

Participants

Reaction Steps

7-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (0.10 g) was dissolved in acetic acid (10 mL) under N2, PtO2 (5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 1 day. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

Provenance & Evidence