Hydrazine → HCID 178518915, compound

HRID 567715Notes

Reaction equation

HRID 567715 reaction equation
[NH2:1][NH2:2].[F:3][C:4]1[CH:21]=[CH:20][C:7]([CH2:8][C:9]([C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13](O)=[O:14])=O)=[CH:6][CH:5]=1>>[F:3][C:4]1[CH:21]=[CH:20][C:7]([CH2:8][C:9]2[C:11]3[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:13]([OH:14])=[N:2][N:1]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 137999822-(4-Fluorobenzylcarbonyl)benzoic acid

Product 1

HCID 178518915HCID 178518915, compound

Procedure

A 3 M ethanolic solution of hydrazine (20 ml, 60 mmol) is added to 2-(4-fluorobenzyl carbonyl)benzoic acid (5.5 g, 20 mmol), and the mixture is stirred at room temperature for 5 hours. Precipitation gives 4-(4-fluorobenzyl)-1-hydroxy-phthalazine.

Workup

  1. customPrecipitation

Sources & evidence

ORD record
ord-41bd89e2715e4c33a2a322bab750b0bd
Source dataset
uspto-grants-2001_01
Patent number
US06180629B2

Reaction notes

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