Benzoyl chloride → HCID 21262529, compound

HRID 567719Notes

Reaction equation

HRID 567719 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:9]2[C:4](=[C:5]([F:19])[CH:6]=[CH:7][C:8]=2[F:18])[C:3]1=[O:20].[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>ClCCl>[F:18][C:8]1[CH:7]=[CH:6][C:5]([F:19])=[C:4]2[C:9]=1[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)=[N:11][N:2]([NH:1][C:21](=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:3]2=[O:20]

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 21262524HCID 21262524, compound

Product 1

HCID 21262529HCID 21262529, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of part C, 2-amino-5,8-difluoro-4-(2-pyridyl)-(2H)-1-phthalazinone (0.01 mol) is stirred overnight with benzoylchloride in dichloromethane at room temperature. The product is recrystallized to yield the title compound (R1=benzyl, Y1=—NH—C(O), R2=2-pyridyl, A=benzene, R3=F, F, m=2, p=0).

Workup

  1. customThe product is recrystallized

Sources & evidence

ORD record
ord-594a0734281f48498e20601dd875fccf
Source dataset
uspto-grants-2001_01
Patent number
US06180629B2

Reaction notes

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