HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-butanone → 4-(3-chloroanilino)-6-(4-ethylthiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-butanone | HCID 13156 | — |
| Reactant | 4-(3-chloroanilino)-6-(thiocarbamoyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21262656 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(3-chloroanilino)-6-(4-ethylthiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 135702836 | — |
Reaction Steps
57.5 mg (0.19 mmol) of 4-(3-chloroanilino)-6-(thiocarbamoyl)-7H-pyrrolo[2,3-d]pyrimidine (see Example 10) and 34 ml of 1-bromo-2-butanone (Aldrich; Milwaukee/USA) in 3 ml of dioxane are heated to boiling for 2 h. Cooling, filtering the suspension and washing with isopropanol/diethyl ether yields 4-(3-chloroanilino)-6-(4-ethylthiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine; HPLC: tRet(Grad20)=13.6; FAB-MS: (M+H)+=356.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180636B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-ddc511c7733c4bcd91fecbe584342563 |
| Source note | uspto-grants-2001_01 |