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HRID567761

反应详情

EQUATION

反应方程式

HRID 567761 的结构方程式

REACTANTS

反应物

2
结构：CCC(=O)CBr
HCID13156

2-Butanone, 1-bromo-

C4H7BrO

结构：NC(=S)c1cc2c(Nc3cccc(Cl)c3)ncnc2[nH]1
HCID21262656

未命名化合物

PRODUCTS

生成物

1
结构：CCc1csc(-c2cc3c(Nc4cccc(Cl)c4)ncnc3[nH]2)n1
HCID135702836

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

57.5 mg (0.19 mmol) of 4-(3-chloroanilino)-6-(thiocarbamoyl)-7H-pyrrolo[2,3-d]pyrimidine (see Example 10) and 34 ml of 1-bromo-2-butanone (Aldrich; Milwaukee/USA) in 3 ml of dioxane are heated to boiling for 2 h. Cooling, filtering the suspension and washing with isopropanol/diethyl ether yields 4-(3-chloroanilino)-6-(4-ethylthiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine; HPLC: tRet(Grad20)=13.6; FAB-MS: (M+H)+=356.

WORKUP

后处理

  1. temperatureCooling
  2. filtrationfiltering the suspension
  3. washwashing with isopropanol/diethyl ether