HCID 21262653, compound → HCID 20639598, compound

HRID 567764Notes

Reaction equation

HRID 567764 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=3)[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1>C(O)CCC>[N+:17]([C:13]1[CH:12]=[C:11]([C:9]2[NH:8][C:4]3[N:5]=[CH:6][N:7]=[C:2]([NH:8][C@@H:9]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[CH3:10])[C:3]=3[CH:10]=2)[CH:16]=[CH:15][CH:14]=1)([O-:19])=[O:18]

Participants

3

Reactant 1

HCID 21262653HCID 21262653, compound

Product 1

HCID 20639598HCID 20639598, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Analogously to the method described in stage 19.4, boiling 20.0 g (700 mmol) of 4-chloro-6-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine (prepared analogously to stages 19.1 to 19.3) with 23.1 ml (168 mmol) of (R)-phenylethylamine in 23.1 ml of n-butanol gives (R)-6-(3-nitrophenyl)-4-[(1-phenylethyl)amino]-7H-pyrrolo-[2,3-d]pyrimidine as rust-brown crystals of m.p.>250° C.; MS: M+=359.

Sources & evidence

ORD record
ord-f8009fb06fbb4cd09dabbdfa50f983fb
Source dataset
uspto-grants-2001_01
Patent number
US06180636B2

Reaction notes

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