Sodium Hydroxide → HCID 131722285, compound

Participants

Reaction Steps

3.53 g (9.0 mmol) of 4-(3-chloroanilino)-6-(4-ethoxycarbonylphenyl)-7H-pyrrolo[2,3-d]pyrimidine are suspended in 150 ml of THF. At 54° C., a total of 0.845 g (21.6 mmol) of lithium aluminum hydride are introduced in the course of 5 h. For working up, 1 ml of water, 2 ml of 1N sodium hydroxide solution and 1 ml of water, followed by 10 g of sodium sulfate, are added successively. The solid is filtered off and the filtrate is concentrated. The residue obtained is washed with methanol and diethyl ether and then dried. 4-(3-Chloroanilino)-6-(4-hydroxymethlyphenyl)-7H-pyrrolo[2,3-d]pyrimidine is obtained in colorless crystals; m.p.>250° C.; FAB-MS (M+H)+=351.

Provenance & Evidence