(S)-Rabeprazole sodium → 2-{[4-(3-methoxylpropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole Sodium Salt Acetone

HRID 567791Notes

Reaction equation

[Na:1].[CH3:2][O:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][S:15]([C:17]2[NH:21][C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[N:18]=2)=[O:16])[C:9]=1[CH3:26]>CC(C)=O>[CH3:9][C:8]([CH3:13])=[O:7].[Na:1].[CH3:2][O:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][S:15]([C:17]2[NH:18][C:19]3[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=3[N:21]=2)=[O:16])[C:9]=1[CH3:26]

Participants

Conditions

Temperature: 24 °C

Procedure

2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole sodium salt (10.0 g) was dissolved in acetone (50 ml). After the mixture was stirred at 24° C. for 23 hours, the precipitated white crystals were filtered and washed with acetone (10 ml) The product was dried at 2220 C. for 20 hours under reduced pressure to give the title compound (11.2 g).

Workup

filtrationthe precipitated white crystals were filtered
washwashed with acetone (10 ml) The product
customwas dried at 2220 C

Sources & evidence

ORD record: ord-05bfa616698843478dbd4d241c95207e
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06180652B2

Reaction notes

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