HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-{[4-(3-methoxylpropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole Sodium Salt Acetone → (S)-Rabeprazole sodium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-{[4-(3-methoxylpropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole Sodium Salt Acetone | HCID 131722286 | — |
| Solvent | Water | HCID 962 | — |
| Product | (S)-Rabeprazole sodium | HCID 9821387 | 101.4% |
Reaction Steps
After the acetone complex (10.0 g) obtained in Example 7 was dissolved in distilled water (20 ml), it was frozen in a dry ice/methanol bath. It was then lyophilized for 48 hours to give the amorphous title compound (8.8 g) (yield: quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180652B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-0d2c12348acd42ba8f9e9b4970f77f60 |
| Source note | uspto-grants-2001_01 |