反应详情

3,4-Dimethoxybenzoylacetonitrile (3.6 g) was dissolved in ethanol (20 ml) to which was subsequently added hydrazine monohydrate (0.87 ml) under cooling with ice. The mixture was heated under reflux for 7 hours and allowed to cool. Then, the solvent was distilled away under a reduced pressure. The resultant residue was recrystallized from ethyl acetate to obtain the title compound (2.92 g) as colorless crystals (melting point: 124-125° C.).

1. temperatureunder cooling with ice
2. temperatureThe mixture was heated
3. temperatureunder reflux for 7 hours
4. temperatureto cool
5. distillationThen, the solvent was distilled away under a reduced pressure
6. customThe resultant residue was recrystallized from ethyl acetate