Water → [(2R)-1-(2-methylpropyl)pyrrolidin-2-yl]methanamine

Lithium aluminum hydride [1.0mol soln. in tetrahydrofuran] (11.52 ml, 11.52 mmol) was added to a solution of (2R)-1-isobutyl-2-pyrrolidinecarboxamide (1.3 g, 7.68 mmol) [see preparation 59] in tetrahydrofuran (5 ml) @0° C. The reaction mixture was stirred for 10 mins and then heated to reflux for 6 hrs. Water (0.5 ml) was added to the cooled mixture followed by sodium hydroxide (1.5 ml) and water (1.5 ml). Tetrahydrofuran (10 ml) was added and the mixture was stirred at room temperature for 1 hr. The aluminum salts were removed by filtration and washed well with diethyl ether. The filtrate was then evaporated under reduced pressure to afford the title compound as a white solid, 705 mg, (58%).

1. temperatureheated
2. temperatureto reflux for 6 hrs
3. stirringthe mixture was stirred at room temperature for 1 hr
4. customThe aluminum salts were removed by filtration
5. washwashed well with diethyl ether
6. customThe filtrate was then evaporated under reduced pressure

ORD record

ord-353e72b55f9144b49667725b3243e755

Source dataset

uspto-grants-2001_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06180627B2