2-Piperidinecarboxamide, (R)- → Ammonia

HRID 567832Notes

Reaction equation

HRID 567832 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]1[C:7]([NH2:9])=[O:8].[CH2:10]1[CH:12]([CH:13](O)C#[N:15])[CH2:11]1>>[CH:12]1([CH2:13][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]2[C:7]([NH2:9])=[O:8])[CH2:10][CH2:11]1.[NH3:15]

Participants

4

Reactant 2

HCID 70621612-Piperidinecarboxamide, (R)-HCID 113893592-Cyclopropyl-2-hydroxyacetonitrile

Product 2

HCID 222AmmoniaHCID 54480503(2R)-1-(cyclopropylmethyl)-2-piperidinecarboxamide

Procedure

The title compound was prepared by a similar method to preparation 57 from (2R)-2-piperidinecarboxamide [see preparation 68] and cyclopropylcarboxaldehye. The crude compound was purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (92:7:1) as the eluant to afford the product as a white solid, (44%).

Workup

  1. customThe crude compound was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-6963233142bf412bb88afc8a3ea64a00
Source dataset
uspto-grants-2001_01
Patent number
US06180627B2

Reaction notes

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