HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidinecarboxamide, (R)- → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidinecarboxamide, (R)- | HCID 7062161 | — |
| Reactant | 2-Cyclopropyl-2-hydroxyacetonitrile | HCID 11389359 | — |
| Product | Ammonia | HCID 222 | — |
| Product | (2R)-1-(cyclopropylmethyl)-2-piperidinecarboxamide | HCID 54480503 | — |
Reaction Steps
The title compound was prepared by a similar method to preparation 57 from (2R)-2-piperidinecarboxamide [see preparation 68] and cyclopropylcarboxaldehye. The crude compound was purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (92:7:1) as the eluant to afford the product as a white solid, (44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06180627B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-6963233142bf412bb88afc8a3ea64a00 |
| Source note | uspto-grants-2001_01 |