Methyl iodide → HCID 22258017, compound

HRID 567898Notes

Reaction equation

HRID 567898 reaction equation
[C:1]([NH:4][C:5](=[O:27])[N:6]([CH:24]([CH3:26])[CH3:25])[C:7]1[S:8][C:9]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:10][C:11]=1[C:12](OCC)=[O:13])(=O)C.[O-]CC.[Na+].IC>>[CH3:1][N:4]1[C:12](=[O:13])[C:11]2[CH:10]=[C:9]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[S:8][C:7]=2[N:6]([CH:24]([CH3:26])[CH3:25])[C:5]1=[O:27]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 2723922Sodium ethoxideHCID 22257976HCID 22257976, compound

Product 1

HCID 22258017HCID 22258017, compound

Procedure

Prepared from N′-acetyl-N-(1-methylethyl)-N-[3-ethoxycarbonyl-5-(phenylmethyl)-2-thienyl]urea (700 mg), sodium ethoxide (400 mg) and iodomethane (0.45 ml) following the method of Example 12, step d) to give the title compound.

Sources & evidence

ORD record
ord-a0b8d0c4cc094032b2d1db86a54fc4cd
Source dataset
uspto-grants-2001_01
Patent number
US06180635B2

Reaction notes

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