Trifluoroacetic acid → HCID 117622817, compound

HRID 56793Notes

Reaction equation

HRID 56793 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]#[N:29])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH2:25][F:26])[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:27])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]#[N:29])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH2:25][F:26])[C:17]([OH:19])=[O:18])[C:10](=[O:27])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622736HCID 117622736, compound

Product 1

HCID 117622817HCID 117622817, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

359 mg (853 μmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-fluorobutanoate (racemate) in 8.5 ml of dichloromethane and 2.5 ml (32 mmol) of TFA were reacted according to General Method 6A. Yield: 306 mg (96% of theory)

Sources & evidence

ORD record
ord-9426ab464e6f4ff49f17bbdadf7cbe4c
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

Loading…