2-Ethylphenyl isocyanate → N-(2-hydroxy-4-nitrophenyl)-N'-(2-ethylphenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Ethylphenyl isocyanate	HCID 583486	—
Reactant	2-Amino-5-Nitrophenol	HCID 4984721	—
Product	N-(2-hydroxy-4-nitrophenyl)-N'-(2-ethylphenyl)urea	HCID 21184795	45.1%

Reaction Steps

N-(2-Hydroxy-4-nitrophenyl)-N′-(2-ethylphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (500 mg, 3.24 mmol) and 2-ethylphenylisocyanate (3.24 mmol) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound(0.44 g, 43%). EI-MS m/z 302(M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06180675B2
Source dataset	uspto-grants-2001_01
ORD ID	ord-cb9432501810406d982d44fe59027dfd
Source note	uspto-grants-2001_01