2-Bromophenyl isocyanate → N-(2-hydroxy 3,4-difluorophenyl) N'-(2-bromophenyl)urea

HRID 568007Notes

Reaction equation

HRID 568007 reaction equation
[OH:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]=[C:19]=[O:20]>>[OH:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:19]([NH:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[Br:11])=[O:20]

Participants

3

Reactant 2

HCID 1370972-Bromophenyl isocyanateHCID 27784416-Amino-2,3-difluorophenol

Product 1

HCID 22011339N-(2-hydroxy 3,4-difluorophenyl) N'-(2-bromophenyl)urea

Procedure

The urea was prepared from 2-hydroxy 3,4-difluoro aniline(0.290 g, 2 mmol) and 2-bromophenylisocyanate(0.4 g) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane(0.254 g, 37%). EI-MS m/z 343(M+H)+.

Workup

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane(0.254 g, 37%)

Sources & evidence

ORD record
ord-b6e22af946f446339b0eccb553ad24ff
Source dataset
uspto-grants-2001_01
Patent number
US06180675B2

Reaction notes

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