Trifluoroacetic acid → HCID 86756344, compound

Participants

Reaction Steps

A stirred solution of 30.8 g (113 mmole) of N-[(1,1-dimethylethoxy)carbonyl]-N-ethylglycine ethyl ester in 50 mL dichloromethane at 3° C. is treated with 200 mL of 1:1 (volume/volume) trifluoroacetic acid in dichloromethane. The reaction mixture is stirred for 2 hours while warming to ambient temperature. The reaction mixture is concentrated in vacuo and the residual highly mobile oil is subjected to high vacuum to give the desired compound (55.2 g), which is used without further purification.

Provenance & Evidence