Trifluoroacetic acid → HCID 86756344, compound

HRID 568110Notes

Reaction equation

HRID 568110 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6](C(OC(C)(C)C)=O)[CH2:7][CH3:8])[CH3:2].[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[CH2:1]([O:3][C:4](=[O:16])[CH2:5][NH:6][CH2:7][CH3:8])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21263324HCID 21263324, compound

Product 1

HCID 86756344HCID 86756344, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A stirred solution of 30.8 g (113 mmole) of N-[(1,1-dimethylethoxy)carbonyl]-N-ethylglycine ethyl ester in 50 mL dichloromethane at 3° C. is treated with 200 mL of 1:1 (volume/volume) trifluoroacetic acid in dichloromethane. The reaction mixture is stirred for 2 hours while warming to ambient temperature. The reaction mixture is concentrated in vacuo and the residual highly mobile oil is subjected to high vacuum to give the desired compound (55.2 g), which is used without further purification.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-02f8374c994b471c95796401589708fa
Source dataset
uspto-grants-2001_01
Patent number
US06180759B2

Reaction notes

Loading…