Hydrogen Bromide → 1,3-Di-n-butyl-8-bromo Xanthine

HRID 568136Notes

Reaction equation

[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([N+]([O-])=O)=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[BrH:23]>>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([Br:23])=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 99444751,3-Di-n-butyl-8-nitro Xanthine

Product 1

HCID 101544891,3-Di-n-butyl-8-bromo Xanthine

Procedure

1,3-Di-n-butyl-8-bromo xanthine was prepared from 1,3-di-n-butyl-8-nitro xanthine (0.5 g, 0.0016 mol) and concentrated hydrobromic acid (8 ml) using the procedure as described in Example 15. The title product was obtained after recrystallisation from ethanol, yield 0.4 g (91%), m.pt. 178° C.

Sources & evidence

ORD record: ord-e39a6ff142a34425999cf22eda600e83
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06180791B2

Reaction notes

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