反应详情

1,3-Di-n-butyl-8-bromo xanthine (2 g, 0.0029 mol) was dissolved in toluene (50 ml). After addition of piperidine (5 g, 0.0058 mol) the mixture was refluxed for 9 hours. The reaction mixture was then extracted with water (4'30 ml), the organic layer dried over anhydrous sodium sulphate and the solvent removed in vacuo. The residue was recrystallised from ethanol to give the title product, yield 0.4 g (20%), m.pt. 221° C.

1. temperaturewas refluxed for 9 hours
2. extractionThe reaction mixture was then extracted with water (4'30 ml), the organic layer
3. dry with materialdried over anhydrous sodium sulphate
4. customthe solvent removed in vacuo
5. customThe residue was recrystallised from ethanol