Lithium Hydroxide → HCID 117622978, compound

HRID 56823Notes

Reaction equation

HRID 56823 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([O:22][CH2:23][CH3:24])[C:17]([O:19]CC)=[O:18])[C:10](=[O:25])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([O:22][CH2:23][CH3:24])[C:17]([OH:19])=[O:18])[C:10](=[O:25])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117622855Ethyl [4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl](ethoxy)acetate

Product 1

HCID 117622978HCID 117622978, compound

Procedure

277 mg (0.69 mmol) of ethyl [4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl](ethoxy)acetate (racemate) were hydrolysed with lithium hydroxide according to General Method 6B. Yield: 180 mg (71% of theory)

Sources & evidence

ORD record
ord-1f6a8351003e4d6282fac9043ecc73b3
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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