Trifluoroacetic acid → HCID 117622592, compound

HRID 56825Notes

Reaction equation

HRID 56825 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:24])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:10](=[O:24])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622654tert-Butyl [4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]acetate

Product 1

HCID 117622592HCID 117622592, compound

Procedure

187 mg (500 μmol) of tert-butyl [4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]acetate and 770 μl (10.0 mmol) of TFA were reacted according to General Method 6A. Yield: 159 mg (93% of theory)

Sources & evidence

ORD record
ord-86280ea2e5af4788ad170d416343ba63
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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