Diisopropyl Ether → HCID 21262448, compound

Participants

Reaction Conditions

Reaction Steps

Thionyl chloride (12.7 ml) is added to 6.67 g of 3-hydroxymethylimidazo[5,1-b]thiazole hydrochloride, and the mixture is stirred at 60° C. for 30 min. The temperature is returned to room temperature, isopropyl ether is added thereto, the supernatant is decanted, and the residue is dried under reduced pressure to give 3-chloromethylimidazo[5,1-b]thiazole hydrochloride. This compound is dissolved in 35 ml of DMF, 10.11 g of triphenylphosphine is added thereto, and the mixture is stirred at 100° C. for 12 hr. The resultant precipitate is collected by filtration to give 8.86 g of (imidazo[5,1-b]thiazol-3-yl)methyltriphenylphosphonium chloride hydrochloride.

Provenance & Evidence