Diisopropyl Ether → HCID 21262448, compound

HRID 568282Notes

Reaction equation

HRID 568282 reaction equation
S(Cl)([Cl:3])=O.[ClH:5].O[CH2:7][C:8]1[N:9]2[CH:15]=[N:14][CH:13]=[C:10]2[S:11][CH:12]=1.C(OC(C)C)(C)C>>[ClH:3].[Cl:5][CH2:7][C:8]1[N:9]2[CH:15]=[N:14][CH:13]=[C:10]2[S:11][CH:12]=1

Participants

4

Reactant 3

HCID 7914Diisopropyl EtherHCID 24386Thionyl ChlorideHCID 21262392HCID 21262392, compound

Product 1

HCID 21262448HCID 21262448, compound

Conditions

Temperature
60 °C

Procedure

Thionyl chloride (12.7 ml) is added to 6.67 g of 3-hydroxymethylimidazo[5,1-b]thiazole hydrochloride, and the mixture is stirred at 60° C. for 30 min. The temperature is returned to room temperature, isopropyl ether is added thereto, the supernatant is decanted, and the residue is dried under reduced pressure to give 3-chloromethylimidazo[5,1-b]thiazole hydrochloride. This compound is dissolved in 35 ml of DMF, 10.11 g of triphenylphosphine is added thereto, and the mixture is stirred at 100° C. for 12 hr. The resultant precipitate is collected by filtration to give 8.86 g of (imidazo[5,1-b]thiazol-3-yl)methyltriphenylphosphonium chloride hydrochloride.

Workup

  1. customis returned to room temperature
  2. customthe supernatant is decanted
  3. customthe residue is dried under reduced pressure

Sources & evidence

ORD record
ord-e4cf404d1b004f0c839f857da4ea21fd
Source dataset
uspto-grants-2001_01
Patent number
US06180622B2

Reaction notes

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