Thionyl Chloride → HCID 21262386, compound

HRID 568285Notes

Reaction equation

HRID 568285 reaction equation
[ClH:1].O[CH2:3][C:4]1[S:8][C:7]2=[CH:9][N:10]=[CH:11][N:6]2[CH:5]=1.S(Cl)([Cl:14])=O>C1COCC1>[ClH:14].[Cl:1][CH2:3][C:4]1[S:8][C:7]2=[CH:9][N:10]=[CH:11][N:6]2[CH:5]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21262373HCID 21262373, compound

Product 1

HCID 21262386HCID 21262386, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

2-Hydroxymethylimidazo[5,1-b]thiazole hydrochloride (1.40 g) is suspended in 15 ml of THF, 0.8 ml of thionyl chloride is added thereto, and the mixture is stirred at 60° C. for 1.5 hr. The solvent is removed by evaporation to give 2-chloromethylimidazo[5,1-b]thiazole hydrochloride. This compound is dissolved in 7 ml of DMF, 1.78 g of triphenylphosphine is added thereto, and the mixture is stirred at 100° C. for 12 hr. The resultant precipitate is collected by filtration to give 2.14 g of (imidazo[5,1-b]thiazol-2-yl)methyltriphenylphosphonium chloride hydrochloride.

Workup

  1. customThe solvent is removed by evaporation

Sources & evidence

ORD record
ord-d5b712c4ac714f868267d6fb2815386a
Source dataset
uspto-grants-2001_01
Patent number
US06180622B2

Reaction notes

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