Water → 6-Chloro-3-hydrazinylpyridazin-4-amine

HRID 568304Notes

Reaction equation

HRID 568304 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][C:3]=1Cl.O.[NH2:11][NH2:12].O>C(O)C>[NH:11]([C:3]1[N:4]=[N:5][C:6]([Cl:8])=[CH:7][C:2]=1[NH2:1])[NH2:12]

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 2984983,6-Dichloropyridazin-4-amine

Product 1

HCID 2500056-Chloro-3-hydrazinylpyridazin-4-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred solution of 2.0 grams of 4-amino-3,6-dichloropyridazine and 2.5 ml of hydrazine hydrate in 20 ml of ethanol is heated under reflux for three hours. After this time water is added to the reaction mixture and the resultant precipitate collected by filtration. The filter cake is recrystallized from ethanol to yield 2.3 grams of 3-hydrazino-4-amino-6-chloropyridazine; m.p. 190° C.

Workup

  1. temperatureunder reflux for three hours
  2. filtrationthe resultant precipitate collected by filtration
  3. customThe filter cake is recrystallized from ethanol

Sources & evidence

ORD record
ord-9262f59e53564d418d7ceaa4d65c56e9
Source dataset
uspto-grants-1988_03
Patent number
US04728355

Reaction notes

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