Isopropylamine → HCID 14099151, compound

HRID 568310Notes

Reaction equation

HRID 568310 reaction equation
[Cl:1][C:2]1[C:3]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:4][N:5]=[N:6][C:7]=1[Cl:8].[CH3:19][CH:20]([NH2:22])[CH3:21]>O1CCCC1>[Cl:1][C:2]1[C:3]([NH:9][C:10]([NH:22][CH:20]([CH3:21])[CH3:19])=[O:18])=[CH:4][N:5]=[N:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 14099148HCID 14099148, compound

Product 1

HCID 14099151HCID 14099151, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A stirred solution of 1.0 gram (0.004 mole) of phenyl N-(5,6-dichloro-4-pyridazinyl)carbamate and 0.27 gram (0.005 mole) of 1-methylethylamine in tetrahydrofuran is heated under reflux for 18 hours. The reaction mixture is filtered and the filtrate concentrated under reduced pressure to a residue. The residue is purified by column chromatography to yield 0.1 gram of N-(5,6-dichloro-4-pyridazinyl)-N'-(1-methylethyl)urea.

Workup

  1. temperatureunder reflux for 18 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate concentrated under reduced pressure to a residue
  4. customThe residue is purified by column chromatography

Sources & evidence

ORD record
ord-ff257fe9cf084077a7b0f2cca3e149f0
Source dataset
uspto-grants-1988_03
Patent number
US04728355

Reaction notes

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