反应详情

A stirred solution of 2.0 grams of phenyl N-(4-pyridazinyl)carbamate (prepared as in Example 2, Step A) and 0.9 gram of N-cyclopentyl-N-methyl amine in tetrahydrofuran is heated under reflux for 18 hours. The reaction mixture is filtered and the filtrate concentrated under reduced pressure to a residue. The residue is purified by column chromatography on silica gel to yield N-(4-pyridazinyl)-N'-cyclopentyl-N'-methylurea.

1. temperatureunder reflux for 18 hours
2. filtrationThe reaction mixture is filtered
3. concentrationthe filtrate concentrated under reduced pressure to a residue
4. customThe residue is purified by column chromatography on silica gel