Ethylamine → HCID 13745537, compound

HRID 568334Notes

Reaction equation

HRID 568334 reaction equation
CS[C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[NH:5][C:6]([C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)=[N:7]2.[CH2:18]([NH2:20])[CH3:19]>O>[CH2:18]([NH:20][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[NH:5][C:6]([C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)=[N:7]2)[CH3:19]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 14097195HCID 14097195, compound

Product 1

HCID 13745537HCID 13745537, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 6 g of 6-methylthio-8-(4-pyridyl)purine, 30 ml of an aqueous solution of 70% ethylamine and 30 ml of water is stirred at 150° C. for 10 hours in an autoclave. The reaction mixture is concentrated and the residual oil is dissolved into methanol. To the solution is added about 3 g of activated charcoal. The mixture is shaken well, filtered and then concentrated. The resulting crystals are recrystallized from a 1:1 mixture of ethanol and water to give 1.7 g of 6-ethylamino-8-(4-pyridyl)purine, melting at 308°-310° C. The following compounds can also be prepared in a similar manner as the above examples and according to the methods described in the specification:

Workup

  1. concentrationThe reaction mixture is concentrated
  2. dissolutionthe residual oil is dissolved into methanol
  3. additionTo the solution is added about 3 g of activated charcoal
  4. stirringThe mixture is shaken well
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe resulting crystals are recrystallized from a 1:1 mixture of ethanol and water

Sources & evidence

ORD record
ord-c8b4e6eded984637adf75353b5c72020
Source dataset
uspto-grants-1988_03
Patent number
US04728644

Reaction notes

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