Ethylamine → HCID 13745537, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6 g of 6-methylthio-8-(4-pyridyl)purine, 30 ml of an aqueous solution of 70% ethylamine and 30 ml of water is stirred at 150° C. for 10 hours in an autoclave. The reaction mixture is concentrated and the residual oil is dissolved into methanol. To the solution is added about 3 g of activated charcoal. The mixture is shaken well, filtered and then concentrated. The resulting crystals are recrystallized from a 1:1 mixture of ethanol and water to give 1.7 g of 6-ethylamino-8-(4-pyridyl)purine, melting at 308°-310° C. The following compounds can also be prepared in a similar manner as the above examples and according to the methods described in the specification:

Provenance & Evidence