反应详情

Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide (2.0 g) was added portionwise with stirring to 98% sulphuric acid (15 cm3) at room temperature. After 16 hours the solution was poured onto ice (100 cm3) and the resulting precipitate was filtered off and dried (1.5 g). Recrystallisation from ethyl acetate-methanol afforded 6-bromo-8-methyl-2-(1H)-quinolone, m.p. 272°-274°.

1. additionAfter 16 hours the solution was poured onto ice (100 cm3)
2. filtrationthe resulting precipitate was filtered off
3. customdried (1.5 g)
4. customRecrystallisation from ethyl acetate-methanol