HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 6-Bromo-8-methylquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide | HCID 14221021 | — |
| Product | 6-Bromo-8-methylquinolin-2(1H)-one | HCID 13836183 | — |
Reaction Steps
Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide (2.0 g) was added portionwise with stirring to 98% sulphuric acid (15 cm3) at room temperature. After 16 hours the solution was poured onto ice (100 cm3) and the resulting precipitate was filtered off and dried (1.5 g). Recrystallisation from ethyl acetate-methanol afforded 6-bromo-8-methyl-2-(1H)-quinolone, m.p. 272°-274°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728654 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-2f35b15b5b12442eafa8bca4cdd5cade |
| Source note | uspto-grants-1988_03 |