Hydrochloric Acid → 8-methyl-6-(1,2,4-triazol-4-yl)-2-(1H)-quinolone hydrochloride

HRID 568367Notes

Reaction equation

HRID 568367 reaction equation
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([CH3:18])[CH:7]=[C:8]([N:13]3[CH:17]=[N:16][N:15]=[CH:14]3)[CH:9]=2)[N:4]=1.[ClH:19]>>[ClH:19].[CH3:18][C:6]1[CH:7]=[C:8]([N:13]2[CH:14]=[N:15][N:16]=[CH:17]2)[CH:9]=[C:10]2[C:5]=1[NH:4][C:3](=[O:2])[CH:12]=[CH:11]2

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 198670672-Methoxy-8-methyl-6-(1,2,4-triazol-4-yl)-quinoline

Product 1

HCID 1317154608-methyl-6-(1,2,4-triazol-4-yl)-2-(1H)-quinolone hydrochloride

Procedure

The following compound, m.p.>350°, was prepared similarly to the previous Example, starting from 2-methoxy-8-methyl-6-(1,2,4-triazol-4-yl)-quinoline and 5M HCl, except that, after refluxing the methoxy starting material with 5M HCl and cooling, the hydrochloride 1/4 hydrate crystallised out of solution and was filtered off and dried. ##STR60##

Workup

  1. temperaturecooling
  2. customthe hydrochloride 1/4 hydrate crystallised out of solution
  3. filtrationwas filtered off
  4. customdried

Sources & evidence

ORD record
ord-e6f54a07d1284fe8bfab25d6b13dbc5d
Source dataset
uspto-grants-1988_03
Patent number
US04728653

Reaction notes

Loading…