反应详情

Sodium hydroxide (18.868, 0.47M) was dissolved in water (150 ml) and added to a stirred mixture of aminoacetonitrile bisulphate (24.23 g, 0.157M) and 4-methoxymethyl benzoyl chloride (29.9 g, 0.157M) in ethyl acetate (150 ml). The reaction was stirred for 21/2 hours at room temperature, the ethyl acetate layer was separated off and the aqueous layer re-extracted with ethyl acetate. The ethyl acetate extracts were combined, dried over magnesium sulphate and evaporated to give a white solid. This was recrystallised from chloroform 80:100 petrol to give white plates, (24.5 gm), mpt 107°-108° C.

1. customthe ethyl acetate layer was separated off
2. extractionthe aqueous layer re-extracted with ethyl acetate
3. dry with materialdried over magnesium sulphate
4. customevaporated
5. customto give a white solid
6. customThis was recrystallised from chloroform 80:100 petrol
7. customto give white plates, (24.5 gm), mpt 107°-108° C.