Piperazine → 8-Ethoxy-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

HRID 568433Notes

Reaction equation

HRID 568433 reaction equation
[CH2:1]([O:3][C:4]1[C:9]2[N:10]=[C:11](Cl)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:8]=2[N:7]=[CH:6][N:5]=1)[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:3][C:4]1[C:9]2[N:10]=[C:11]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:8]=2[N:7]=[CH:6][N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 201501578-Ethoxy-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine

Product 1

HCID 201502938-Ethoxy-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

Procedure

This compound was prepared analogous to Example 2 from 8-ethoxy-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine m.p.: 153°-155° C.) and piperazine.

Sources & evidence

ORD record
ord-1f105ab4e0764502afb8c776d6d65b1d
Source dataset
uspto-grants-1988_03
Patent number
US04728646

Reaction notes

Loading…