Piperazine → HCID 12817088, compound

HRID 568472Notes

Reaction equation

HRID 568472 reaction equation
[CH2:1]([N:8]([C:12]1[C:17]2[N:18]=[C:19](Cl)[N:20]=[C:21]([N:22]3[CH2:27][CH2:26][S:25](=[O:28])[CH2:24][CH2:23]3)[C:16]=2[N:15]=[CH:14][N:13]=1)[CH2:9][CH2:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH2:1]([N:8]([CH2:9][CH2:10][OH:11])[C:12]1[C:17]2[N:18]=[C:19]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)[N:20]=[C:21]([N:22]3[CH2:27][CH2:26][S:25](=[O:28])[CH2:24][CH2:23]3)[C:16]=2[N:15]=[CH:14][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 128170348-[N-benzyl-N-(2-hydroxyethyl)-amino]-2-chloro-4-(1-oxido-thiomorpholino)-pyrimido-[5,4-d]-pyrimidine

Product 1

HCID 12817088HCID 12817088, compound

Procedure

This compound was prepared analogous to Example 118 from 8-[N-benzyl-N-(2-hydroxyethyl)-amino]-2-chloro-4-(1-oxido-thiomorpholino)-pyrimido-[5,4-d]-pyrimidine (m.p.: 153°-155° C.) and piperazine.

Sources & evidence

ORD record
ord-d677d44f5e3641faba553d66c29d3dff
Source dataset
uspto-grants-1988_03
Patent number
US04728646

Reaction notes

Loading…