反应详情

温度

-10 °C

A 2.2 g portion 4(1H-imidazol-1-yl)butanamine dihydrochloride and 2 ml of 10N sodium hydroxide in 200 ml of ethanol was stirred for 10 minutes and then treated with 3.2 g of 2-(methylthio)benz[cd]indole hydroiodide. This mixture was heated at reflux for 16 hours and then cooled to -10° C. The mixture was reheated to boiling, clarified while hot and the filtrate cooled to -10° C. The solid was collected, washed with ethanol, then ether and dried at 60° C. in vacuo, giving 2.0 g of the desired product, mp 144°-147° C.

1. temperatureThis mixture was heated
2. temperatureat reflux for 16 hours
3. temperaturecooled to -10° C
4. customThe solid was collected
5. washwashed with ethanol
6. dry with materialether and dried at 60° C. in vacuo