Sodium Hydroxide → HCID 178506531, compound

Participants

Reaction Conditions

Reaction Steps

A 2.2 g portion 4(1H-imidazol-1-yl)butanamine dihydrochloride and 2 ml of 10N sodium hydroxide in 200 ml of ethanol was stirred for 10 minutes and then treated with 3.2 g of 2-(methylthio)benz[cd]indole hydroiodide. This mixture was heated at reflux for 16 hours and then cooled to -10° C. The mixture was reheated to boiling, clarified while hot and the filtrate cooled to -10° C. The solid was collected, washed with ethanol, then ether and dried at 60° C. in vacuo, giving 2.0 g of the desired product, mp 144°-147° C.

Provenance & Evidence