Potassium Hydroxide → HCID 178419292, compound

HRID 568497Notes

Reaction equation

HRID 568497 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[CH:7]=[CH:6][N:5]=[CH:4]1.[OH-].[K+].[Br:15][C:16]1[C:17]2[C:18]3[C:22](=[CH:23][CH:24]=1)[N:21]=[C:20](S)[C:19]=3[CH:26]=[CH:27][CH:28]=2>C(O)C>[Br:15][C:16]1[C:17]2[C:18]3[C:22](=[CH:23][CH:24]=1)[N:21]=[C:20]([NH:12][CH2:11][CH2:10][CH2:9][CH2:8][N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)[C:19]=3[CH:26]=[CH:27][CH:28]=2

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 128033264-(Imidazole-1-yl)butylamine dihydrochlorideHCID 178527759HCID 178527759, compound

Product 1

HCID 178419292HCID 178419292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture 4.2 g of 4-(1H-imidazol-1-yl)butanamine dihydrochloride in 75 ml of ethanol was treated with 2.2 g of potassium hydroxide and stirred for 18 hours. A 5.2 g portion of 6-bromo-benz[cd]indole-2-thiol and 6.4 g of mercuric acetate were added and the reaction proceeded as described in Example 1, giving 3.7 g of the desired product, mp 145°-147° C.

Sources & evidence

ORD record
ord-98e348ef0de74a8ebf2a8e4a02b89482
Source dataset
uspto-grants-1988_03
Patent number
US04728663

Reaction notes

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