Hydrazine hydrate (1:1) → HCID 86160846, compound

HRID 568520Notes

Reaction equation

HRID 568520 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)=O.O.[NH2:18][NH2:19]>C(O)CO>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)=[N:18][NH2:19]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21915324HCID 21915324, compound

Product 1

HCID 86160846HCID 86160846, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A mixture prepared form 18 g of (3-bromothien-2-yl) (4-methoxyphenyl)methanone, 12 ml of hydrazine hydrate (99%) and 120 ml of ethylene glycol was stirred at 120° for 2 hours. Thereafter, the mixture was cooled and diluted with 1000 g of ice water and quickly extracted with ether (3×500 ml). The combined ether solution was washed four times with water to remove unreacted hydrazine and dried over anhydrous magnesium sulfate overnight.

Workup

  1. temperatureThereafter, the mixture was cooled
  2. extractionquickly extracted with ether (3×500 ml)
  3. washThe combined ether solution was washed four times with water
  4. customto remove unreacted hydrazine
  5. dry with materialdried over anhydrous magnesium sulfate overnight

Sources & evidence

ORD record
ord-a002ec5bf8a240718f65bda9ea6697af
Source dataset
uspto-grants-1988_03
Patent number
US04728651

Reaction notes

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