反应详情

A solution of 1-Benzyl-2-chloromethylbenzimidazole hydrochloride (16 g, 0.055 mole) in N,N-dimethylformamide (80 ml) was stirred and a solution of sodium azide (17 g, 0.26 mole) in water (40 ml) was added. The resulting yellow solution was heated on a steam bath for 30 minutes, diluted with water (250 ml) and the crystalline product was filtered, dried in vacuo at room temperature, and recrystallized from 2-propanol to yield 10.5 g (73%) of product: mp 108°-110°.

1. temperatureThe resulting yellow solution was heated on a steam bath for 30 minutes
2. filtrationthe crystalline product was filtered
3. customdried in vacuo at room temperature
4. customrecrystallized from 2-propanol