Trifluoroacetic acid → HCID 117622447, compound

HRID 56866Notes

Reaction equation

HRID 56866 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:31]#[N:32])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH:25]([O:28][CH3:29])[CH2:26][CH3:27])[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:30])[CH:9]=2)[CH:7]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:31]#[N:32])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][CH:25]([O:28][CH3:29])[CH2:26][CH3:27])[C:17]([OH:19])=[O:18])[C:10](=[O:30])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622709tert-Butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxyhexanoate

Product 1

HCID 117622447HCID 117622447, compound

Procedure

668 mg (1.45 mmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxyhexanoate (mixture of racemic diastereomers) were hydrolysed with trifluoroacetic acid according to General Method 6A. Yield: 623 mg (purity 94%, quant.)

Sources & evidence

ORD record
ord-cc15d0c02a634950b2f67092be63933c
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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