Ammonium Hydroxide → HCID 14012524, compound

HRID 568701Notes

Reaction equation

HRID 568701 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[F:17])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:18][CH2:19][C:20](Cl)=[O:21].[OH-].[NH4+:24]>>[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[F:17])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:18][CH2:19][C:20]([NH2:24])=[O:21]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 20150513HCID 20150513, compound

Product 1

HCID 14012524HCID 14012524, compound

Procedure

To 3.5 g of {[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetyl chloride is added 50 ml of conc ammonium hydroxide at 0° C. After stirring for 2 hr the precipitate is filtered and washed with ice-cold acetonitrile. Recrystallization of the filter cake from acetonitrile gives {[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetamide, mp 172° C.

Workup

  1. filtrationis filtered
  2. washwashed with ice-cold acetonitrile
  3. customRecrystallization of the filter cake from acetonitrile

Sources & evidence

ORD record
ord-93dbf04daccc478ebd8842fb3bb54bee
Source dataset
uspto-grants-1988_03
Patent number
US04728662

Reaction notes

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