Trifluoroacetic acid → HCID 117622868, compound

HRID 56878Notes

Reaction equation

HRID 56878 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:33]#[N:34])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]3([C:28]([F:31])([F:30])[F:29])[CH2:27][CH2:26]3)[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:32])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:33]#[N:34])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]3([C:28]([F:30])([F:31])[F:29])[CH2:26][CH2:27]3)[C:17]([OH:19])=[O:18])[C:10](=[O:32])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622884HCID 117622884, compound

Product 1

HCID 117622868HCID 117622868, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

295 mg (594 μmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-[1-(trifluoromethyl)cyclopropyl]propanoate (racemate) in 6 ml of dichloromethane and 915 μl (11.9 mmol) of TFA were reacted according to General Method 6A. Yield: 258 mg (purity 92%, 91% of theory)

Sources & evidence

ORD record
ord-8d7b0e3a4bea4fd490c414bbd2ece9d7
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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