反应详情

Analogously to Example 1, from 960 mg. (5.0 mmole) 5,6-diamino-3,3-dimethylindolin-2-one and 640 mg. (5.0 mmole) cyclohexanecarboxylic acid, after 1.5 hours at 240° C., there is obtained 1.37 g. of crude product. 300 mg. thereof are purified over a silica gel column (elution agent: dichloromethane/methanol 9:1 v/v). After removal of the solvent in a vacuum, there is obtained a greenish oil which is crystallised with diethyl ether. There are obtained 192 mg. (53% of theory) of the title compound in the form of pale brown crystals; m.p. 315°-318° C.

1. customthere is obtained 1.37 g
2. customthereof are purified over a silica gel column (elution agent: dichloromethane/methanol 9:1 v/v)
3. customAfter removal of the solvent in a vacuum
4. customthere is obtained a greenish oil which
5. customis crystallised with diethyl ether
6. customThere are obtained 192 mg