Cyclohexanecarboxylic acid → 7,7-Dimethyl-2-cyclohexyl-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-one

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Reaction Steps

Analogously to Example 1, from 960 mg. (5.0 mmole) 5,6-diamino-3,3-dimethylindolin-2-one and 640 mg. (5.0 mmole) cyclohexanecarboxylic acid, after 1.5 hours at 240° C., there is obtained 1.37 g. of crude product. 300 mg. thereof are purified over a silica gel column (elution agent: dichloromethane/methanol 9:1 v/v). After removal of the solvent in a vacuum, there is obtained a greenish oil which is crystallised with diethyl ether. There are obtained 192 mg. (53% of theory) of the title compound in the form of pale brown crystals; m.p. 315°-318° C.

Provenance & Evidence